Bibliothèque

Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer.

BACKGROUND: Immune checkpoint inhibitors (ICIs) have demonstrated efficacy in the treatment of resectable and advanced gastric cancer. However, their effectiveness in initially unresectable gastric ca…

Thérapies de Conversion

Li, S., Xu, Q., Yu, W., Liu, Z., Cui, X., Wei, M., Shi, D., Zhao, W., Song, X., Zhang, D., Nan, Z., Chu, J., Wang, S., Nie, S., Dai, X., & Liu, L. (2025). Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer.. Front Immunol, 16, 1753749. https://doi.org/10.3389/fimmu.2025.1753749

01/01/2025 Lire →

Case Report: Efficacy of preoperative conversion therapy with lenvatinib, toripalimab, and hepatic arterial infusion chemotherapy in an advanced hepatocellular carcinoma.

Advanced hepatocellular carcinoma (HCC) has a poor prognosis. Conversion therapy based on non-surgical local therapy and drug therapy is an effective treatment for unresectable HCC. We report a case o…

Thérapies de Conversion

Mao, J., Zhang, H., Yang, X., Yao, Y., Sun, X., & Yan, Q. (2025). Case Report: Efficacy of preoperative conversion therapy with lenvatinib, toripalimab, and hepatic arterial infusion chemotherapy in an advanced hepatocellular carcinoma.. Front Oncol, 15, 1627281. https://doi.org/10.3389/fonc.2025.1627281

01/01/2025 Lire →

TPF regimen improves conversion surgery and short-term survival in patients with locally unresectable advanced gastric cancer.

OBJECTIVE: To compare the efficacy and safety of TPF versus FOLFOX regimens in conversion therapy for locally unresectable advanced gastric cancer (LAUGC) and to identify prognostic factors influencin…

Thérapies de Conversion

Duan, T., Ma, D., Bai, Z., Ding, X., & Zhang, X. (2025). TPF regimen improves conversion surgery and short-term survival in patients with locally unresectable advanced gastric cancer.. Am J Transl Res, 17(8), 6068-6079. https://doi.org/10.62347/FFQN8329

01/01/2025 Lire →

Conversion therapy with chemoimmunotherapy induced pCR in a stage IV lung squamous cell carcinoma patient harboring exon 20 insertion.

This case study details an innovative conversion therapy strategy in a 58-year-old Asian male with baseline stage cTNM advanced lung squamous cell carcinoma (SCC) harboring a rare exon 20 insertion m…

Thérapies de Conversion

Xu, M., Huo, X., Zhang, C., Zhang, X., Wang, H., Yang, H., Ge, N., Wang, Y., & Hou, H. (2024). Conversion therapy with chemoimmunotherapy induced pCR in a stage IV lung squamous cell carcinoma patient harboring exon 20 insertion.. Hum Vaccin Immunother, 20(1), 2431384. https://doi.org/10.1080/21645515.2024.2431384

31/12/2024 Lire →

Non-surgery strategy versus hepatectomy in hepatocellular carcinoma patients with complete response after conversion therapy: a meta-analysis.

BACKGROUND: There is ongoing debate surrounding the optimal therapeutic strategy for hepatocellular carcinoma (HCC) patients achieving complete response (CR) after conversion therapy. This meta-analys…

Thérapies de Conversion

Wang, J., Hu, Y., Zhou, L., Yang, Y., Chen, J., Chen, H., & Wang, H. (2024). Non-surgery strategy versus hepatectomy in hepatocellular carcinoma patients with complete response after conversion therapy: a meta-analysis.. World J Surg Oncol, 22(1), 349. https://doi.org/10.1186/s12957-024-03645-6

28/12/2024 Lire →

Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment.

BACKGROUND: Recent studies have highlighted the distinct ratio of PD-1 + Treg/PD-1 + CD8 for prognosis prediction. However, it remains unclear about the association of this ratio and tertiary lymphoid…

Thérapies de Conversion

Liu, X., Xu, D., Zhou, C., Zhong, Y., Geng, H., Huang, C., Shen, Y., Xia, X., Wang, C., Zhu, C., & Cao, H. (2024). Association of PD-1 + Treg/PD-1 + CD8 ratio and tertiary lymphoid structures with prognosis and response in advanced gastric cancer patients receiving preoperative treatment.. J Transl Med, 22(1), 1152. https://doi.org/10.1186/s12967-024-05867-4

27/12/2024 Lire →

Supporting autonomy in young people with gender dysphoria: psychotherapy is not conversion therapy.

Opinion is divided about the certainty of the evidence base for gender-affirming medical interventions in youth. Proponents claim that these treatments are well supported, while critics claim the poor…

Thérapies de Conversion

D'Angelo, R. (2024). Supporting autonomy in young people with gender dysphoria: psychotherapy is not conversion therapy.. J Med Ethics, 51(1), 3-9. https://doi.org/10.1136/jme-2023-109282

23/12/2024 Lire →

Therapeutic types and advantages of functionalized nanoparticles in inducing ferroptosis in cancer therapy.

BACKGROUND: The clinical efficacy of cancer treatment protocols remains unsatisfactory; however, the emergence of ferroptosis-driven therapy strategies has renewed hope for tumor treatment, owing to t…

Thérapies de Conversion

Wang, Z., Zhao, M., Huang, X., Wang, Y., Li, W., Qiao, J., & Yang, X. (2024). Therapeutic types and advantages of functionalized nanoparticles in inducing ferroptosis in cancer therapy.. Ann Med, 56(1), 2396568. https://doi.org/10.1080/07853890.2024.2396568

01/12/2024 Lire →

A Case of Fibrolamellar Hepatocellular Carcinoma in Which Tumor Control Was Achieved by Re-Administering Atezolizumab and Bevacizumab.

BACKGROUND: Fibrolamellar hepatocellular carcinoma (FL-HCC) clinically occurs in young people aged 20-30 years, who often have a normal liver background. We propose a treatment for such cases in which…

Thérapies de Conversion

Hagiwara, S., Oda, I., Ueshima, K., Komeda, Y., Nishida, N., Yoshida, A., Yamamoto, T., Omaru, N., Matsubara, T., & Kudo, M. (2024). A Case of Fibrolamellar Hepatocellular Carcinoma in Which Tumor Control Was Achieved by Re-Administering Atezolizumab and Bevacizumab.. Cancer Rep (Hoboken), 7(12), e70090. https://doi.org/10.1002/cnr2.70090

01/12/2024 Lire →

Oncological Resectability Criteria for Hepatocellular Carcinoma in the Era of Novel Systemic Therapies: The Japan Liver Cancer Association and Japanese Society of Hepato-Biliary-Pancreatic Surgery Expert Consensus Statement 2023.

Recent advances in systemic therapy for hepatocellular carcinoma (HCC) have led to debates about the feasibility of combination therapies, such as systemic therapy combined with surgery or transarteri…

Thérapies de Conversion

Akahoshi, K., Shindoh, J., Tanabe, M., Ariizumi, S., Eguchi, S., Okamura, Y., Kaibori, M., Kubo, S., Shimada, M., Taketomi, A., Takemura, N., Nagano, H., Nakamura, M., Hasegawa, K., Hatano, E., Yoshizumi, T., Endo, I., & Kokudo, N. (2024). Oncological Resectability Criteria for Hepatocellular Carcinoma in the Era of Novel Systemic Therapies: The Japan Liver Cancer Association and Japanese Society of Hepato-Biliary-Pancreatic Surgery Expert Consensus Statement 2023.. Liver Cancer, 13(6), 0-10. https://doi.org/10.1159/000538627

01/12/2024 Lire →

Efficacy of sintilimab combined with neoadjuvant chemotherapy and trastuzumab in conversional treatment of locally advanced HER2-positive gastric cancer: case analysis and literature review.

BACKGROUND: Regional lymph nodes that are fixed and fused into clusters or those exhibiting metastases outside the regional lymph nodes are generally classified as stage IV (M1) or unresectable. Patie…

Thérapies de Conversion

Ibrahim, S., Maimaitiaili, A., Zhu, G., & Ye, S. (2024). Efficacy of sintilimab combined with neoadjuvant chemotherapy and trastuzumab in conversional treatment of locally advanced HER2-positive gastric cancer: case analysis and literature review.. J Cancer Res Clin Oncol, 150(12), 507. https://doi.org/10.1007/s00432-024-06024-6

19/11/2024 Lire →

Complete pathological response in a patient with locally advanced rectal cancer following conversion therapy: A case report.

Thérapies de Conversion

Xue, Y., Zhao, Y., Dong, B., & Yang, X. (2024). Complete pathological response in a patient with locally advanced rectal cancer following conversion therapy: A case report.. Asian J Surg. https://doi.org/10.1016/j.asjsur.2024.10.070

18/11/2024 Lire →